[et_pb_section fb_built=”1″ fullwidth=”on” _builder_version=”4.27.4″ background_color=”#E02B20″ use_background_color_gradient=”on” background_color_gradient_stops=”#7cda24 0%|#2b87da 100%” background_color_gradient_start=”#7cda24″ background_color_gradient_end=”#2b87da” background_image=”http:\/\/labs.iitgn.ac.in\/crystallab\/wp-content\/uploads\/2018\/04\/Crystal-4.jpg” parallax=”on” custom_padding=”0px|0px|0px|0px” background_color_gradient_stops_tablet=”#7cda24 0%|#2b87da 100%” background_color_gradient_stops_phone=”#7cda24 0%|#2b87da 100%” global_module=”205494″ saved_tabs=”all” global_colors_info=”{}”][et_pb_fullwidth_header _builder_version=”4.27.4″ _module_preset=”default” background_color=”#1c1c1c” inline_fonts=”Amethysta” global_colors_info=”{}”]<\/p>\n
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[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Brewing Step” _builder_version=”4.16″ custom_padding=”0px|0px|0px|0px” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ global_colors_info=”{}”]<\/p>\n
Research focus of our lab is towards structure elucidation of small molecules and macromolecules via X-ray crystallography. To answer challenging questions in structural biology of macromolecules and to understand there molecular mechanism & its functions in living cells.<\/p>\n
Major area of research:<\/strong> Structural Biology, Chemical Crystallography and Metabolites Analysis<\/p>\n Structural investigation of chronic disease causing macromolecules as well as understanding their function & mechanism in cells via high resolution X-ray crystallography is the theme of our research. At present the main focus is on ailment causing protein like gamma secretase activating protein (GSAP) a therapeutic target for Alzheimer\u2019s disease and various other proteins in cancer like tetraspanin, IMPDH and TSC (I, II). In addition to X Ray, other biophysical techniques like FPLC, CD, NMR, microscopy and ITC will also be used for binding studies with small molecule drugs and peptides along with investigating different protein crystallization methods to generate high quality single crystals for structural studies.<\/p>\n <\/p>\n Involved in studying the intermolecular weak interactions in small molecule crystals, structural topographies of polymorphism in API\u2019s, in-situ cryo-crystallization of liquids and co-crystallization of API\u2019s with salts, target proteins, peptides.<\/p>\n <\/p>\n Metabolites analysis of Microbiome in ESKAPE pathogens from International Space Station (ISS).\u00a0<\/p>\n <\/p>\n <\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.16″ quote_font=”||||||||” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” column_structure=”1_3,1_3,1_3″][et_pb_column _builder_version=”4.27.4″ _module_preset=”default” type=”1_3″][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” hover_enabled=”0″ sticky_enabled=”0″]<\/p>\n Pharmaceutical Co-crystallization<\/strong><\/p>\n 1. EGFR inhibitor: Gefitinib<\/p>\n Aim: to improve the solubility of the BCS Class II API<\/p>\n 2. Human Glioblastoma inhibitor: Temozolomide<\/p>\n Aim: To improve the Stability of the drug in the tablet form<\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column _builder_version=”4.27.4″ _module_preset=”default” type=”1_3″][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” hover_enabled=”0″ sticky_enabled=”0″]<\/p>\n Polymorphic Studies<\/strong><\/p>\n Dimeric nature of Gefitinib solvate<\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column _builder_version=”4.27.4″ _module_preset=”default” type=”1_3″][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” hover_enabled=”0″ sticky_enabled=”0″]<\/p>\n Genetic\/Neurodegenerative disorders<\/strong><\/p>\n 1.Tuberous sclerosis complex (TSC1\/TSC2)<\/p>\n 2.Gamma secretase activating protein (GSAP)<\/p>\n 3.Folliculin interacting proteins (FNIP1\/FNIP2)<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_divider color=”rgba(0,0,0,0.09)” divider_weight=”3px” _builder_version=”4.16″ global_colors_info=”{}”]<\/p>\n \u00a0<\/p>\n [\/et_pb_divider][et_pb_text _builder_version=”4.16″ text_font=”Nunito||||||||” text_font_size=”18px” text_line_height=”1.8em” header_text_align=”center” header_font_size=”16px” header_letter_spacing=”2px” header_line_height=”1.7em” header_3_font=”Oswald|||on|||||” header_3_font_size=”42px” header_3_letter_spacing=”2px” header_3_line_height=”1.5em” header_4_font=”Oswald|||on|||||” header_4_font_size=”16px” header_4_letter_spacing=”1px” header_4_line_height=”1.5em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”600px” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|phone” module_alignment=”left” custom_margin=”|||” locked=”off” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_image src=”http:\/\/labs.iitgn.ac.in\/crystallab\/wp-content\/uploads\/2018\/04\/Crystallab-research.jpg” align_tablet=”center” align_phone=”center” align_last_edited=”on|desktop” _builder_version=”4.16″ global_colors_info=”{}”]<\/p>\n \u00a0<\/p>\n [\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”SectionBrewing Step” _builder_version=”4.16″ custom_padding=”0px|0px|50.5938px|0px” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_divider color=”rgba(0,0,0,0.09)” divider_weight=”3px” _builder_version=”4.16″ global_colors_info=”{}”]<\/p>\n \u00a0<\/p>\n [\/et_pb_divider][et_pb_image src=”http:\/\/labs.iitgn.ac.in\/crystallab\/wp-content\/uploads\/2018\/04\/Crystallab-research-1.jpg” align_tablet=”center” align_phone=”center” align_last_edited=”on|desktop” _builder_version=”4.16″ global_colors_info=”{}”]<\/p>\n \u00a0<\/p>\n [\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.0.74″ background_color=”#3c3d41″ custom_padding=”0px||0px|” custom_padding_tablet=”0px||0px|” transparent_background=”off” padding_mobile=”on” global_module=”3921″ saved_tabs=”all” global_colors_info=”{}”][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" MACROMOLECULAR AND CHEMICAL CRYSTALLOGRAPHY LAB (MCCL)ResearchResearch focus of our lab is towards structure elucidation of small molecules and macromolecules via X-ray crystallography. To answer challenging questions in structural biology of macromolecules and to understand there molecular mechanism & its functions in living cells. Major area of research: Structural Biology, Chemical Crystallography and Metabolites Analysis Structural […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"page-template-blank.php","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-205466","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/labs.iitgn.ac.in\/crystallab\/wp-json\/wp\/v2\/pages\/205466","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/labs.iitgn.ac.in\/crystallab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/labs.iitgn.ac.in\/crystallab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/labs.iitgn.ac.in\/crystallab\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/labs.iitgn.ac.in\/crystallab\/wp-json\/wp\/v2\/comments?post=205466"}],"version-history":[{"count":10,"href":"http:\/\/labs.iitgn.ac.in\/crystallab\/wp-json\/wp\/v2\/pages\/205466\/revisions"}],"predecessor-version":[{"id":206509,"href":"http:\/\/labs.iitgn.ac.in\/crystallab\/wp-json\/wp\/v2\/pages\/205466\/revisions\/206509"}],"wp:attachment":[{"href":"http:\/\/labs.iitgn.ac.in\/crystallab\/wp-json\/wp\/v2\/media?parent=205466"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Structural biology:<\/h3>\n
Chemical crystallography:<\/h3>\n
Metabolites Analysis:<\/h3>\n
Projects<\/strong><\/h1>\n
Our research approach<\/h3>\n