{"id":2,"date":"2018-02-22T05:05:30","date_gmt":"2018-02-22T05:05:30","guid":{"rendered":"http:\/\/research.iitgn.ac.in\/ccbl\/?page_id=2"},"modified":"2025-06-20T10:23:26","modified_gmt":"2025-06-20T10:23:26","slug":"sample-page","status":"publish","type":"page","link":"http:\/\/labs.iitgn.ac.in\/ccbl\/","title":{"rendered":"Home Page"},"content":{"rendered":"

[et_pb_section fb_built=”1″ fullwidth=”on” _builder_version=”4.16″ custom_padding=”0|0px|5px|0px|false|false” saved_tabs=”all” global_colors_info=”{}”][et_pb_fullwidth_header title=”Dr. Sivapriya Kirubakaran – Cancer Chemical Biology lab ” subhead=”Indian Institute of Technology Gandhinagar” _builder_version=”4.16″ background_color=”rgba(255, 255, 255, 0)” background_image=”http:\/\/labs.iitgn.ac.in\/ccbl\/wp-content\/uploads\/2022\/07\/gettyimages-1349793318-170667a.jpg” text_shadow_style=”preset1″ global_colors_info=”{}” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_fullwidth_header][et_pb_fullwidth_menu menu_id=”7″ submenu_direction=”downwards” fullwidth_menu=”off” _builder_version=”4.16″ menu_font=”|700|||||||” menu_text_color=”#0047e0″ menu_font_size=”16px” text_orientation=”center” global_colors_info=”{}”] 
\n[\/et_pb_fullwidth_menu][et_pb_fullwidth_slider _builder_version=”4.27.4″ background_enable_image=”off” background_size=”contain” hover_enabled=”0″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off” sticky_enabled=”0″][et_pb_slide image=”http:\/\/labs.iitgn.ac.in\/ccbl\/wp-content\/uploads\/2023\/05\/DSC4907-1-scaled.jpeg” _builder_version=”4.27.4″ _module_preset=”default” header_font=”Georgia||||||||” background_color=”#FFFFFF” background_enable_color=”on” background_layout=”light” hover_enabled=”0″ text_shadow_style=”preset3″ global_colors_info=”{}” sticky_transition=”on” title_text=”_DSC4907″ sticky_enabled=”0″]<\/p>\n

“Here’s to a decade of groundbreaking discoveries, tireless research, and endless possibilities – Celebrating 10<\/span> years of excellence in SVL lab!”<\/strong><\/h2>\n

[\/et_pb_slide][\/et_pb_fullwidth_slider][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ custom_padding=”0px|0px|0px|0px” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ text_font=”Georgia||||||||” text_text_color=”#000000″ text_text_shadow_style=”preset3″ global_colors_info=”{}”]<\/p>\n

Recent Lab News<\/strong><\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ fullwidth=”on” _builder_version=”4.16″ global_colors_info=”{}”][et_pb_fullwidth_slider _builder_version=”4.27.4″ background_size=”contain” global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][et_pb_slide image=”http:\/\/labs.iitgn.ac.in\/ccbl\/wp-content\/uploads\/2025\/06\/scientific-reports.png” use_bg_overlay=”off” use_text_overlay=”off” _builder_version=”4.27.4″ header_font=”Georgia||||||||” background_color=”#ffffff” button_on_hover=”on” text_orientation=”justified” background_layout=”light” text_shadow_style=”preset1″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off” sticky_transition=”on”]<\/p>\n

Out Now! Much-awaited Paper.<\/strong><\/h3>\n

TLK1 as a therapeutic target in TMZ-resistant glioblastoma using small-molecule inhibitors!<\/strong><\/h3>\n

This study sheds light on the role of TLK1 in the context of TMZ resistance, highlighting its potential as a valuable target for therapeutic intervention.<\/span><\/strong><\/p>\n

Congratulations! Dr. BhanuPriya<\/span><\/strong><\/p>\n

[\/et_pb_slide][et_pb_slide image=”http:\/\/labs.iitgn.ac.in\/ccbl\/wp-content\/uploads\/2025\/06\/bioorganic.png” use_bg_overlay=”off” use_text_overlay=”off” _builder_version=”4.27.4″ header_font=”Georgia||||||||” background_color=”#ffffff” button_on_hover=”on” text_orientation=”justified” background_layout=”light” text_shadow_style=”preset1″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off” sticky_transition=”on”]<\/p>\n

Another work on the development of new non-ATP-dependent inhibitors of TLK1 for treating prostate cancer.<\/strong><\/h3>\n

These findings provide insights into expanding the range of TLK1 inhibitors and highlight the potential of indole-fused pyridazinone molecules in prostate cancer treatment through the inhibition of the TLK1 pathway.<\/span><\/strong><\/p>\n

Congratulations! Dr. Delna Johnson<\/span><\/strong><\/p>\n

[\/et_pb_slide][et_pb_slide image=”http:\/\/labs.iitgn.ac.in\/ccbl\/wp-content\/uploads\/2025\/06\/chemical-biology-and-drug-design.png” use_bg_overlay=”off” use_text_overlay=”off” _builder_version=”4.27.4″ header_font=”Georgia||||||||” background_color=”#ffffff” button_on_hover=”on” text_orientation=”justified” background_layout=”light” text_shadow_style=”preset1″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off” sticky_transition=”on”]<\/p>\n

Our Recent work in collaboration with Prof. Madulika (IITM) on PTP-PEST.<\/strong><\/h3>\n

The present study aimed to investigate potential PTP-PEST inhibitors via in-silico high-thoughput screening as well as biochemical studies of in-house designed molecules.<\/span><\/strong><\/p>\n

Congratulations again! Dr. Delna and team….<\/span><\/strong><\/p>\n

[\/et_pb_slide][et_pb_slide image=”http:\/\/labs.iitgn.ac.in\/ccbl\/wp-content\/uploads\/2024\/08\/Picture14.png” use_bg_overlay=”off” use_text_overlay=”off” _builder_version=”4.27.4″ header_font=”Georgia||||||||” background_color=”#ffffff” button_on_hover=”on” text_orientation=”justified” background_layout=”light” text_shadow_style=”preset1″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off” sticky_transition=”on”]<\/p>\n

Check out our recent work on targeting TLK1 kinase for GBM Therapy!<\/strong><\/h3>\n

These findings indicate that TLK1 is one of the upregulated kinases in GBM and phenothiazine-based TLK1 inhibitors could be a promising treatment option for GBM patients..<\/span><\/strong><\/p>\n

Congratulations Dr. Bhanu, Dimple, and team!<\/span><\/strong><\/p>\n

[\/et_pb_slide][et_pb_slide image=”http:\/\/labs.iitgn.ac.in\/ccbl\/wp-content\/uploads\/2024\/06\/Picture1.png” use_bg_overlay=”off” use_text_overlay=”off” _builder_version=”4.27.4″ header_font=”Georgia||||||||” background_color=”#ffffff” button_on_hover=”on” text_orientation=”justified” background_layout=”light” text_shadow_style=”preset1″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off” sticky_transition=”on”]<\/p>\n

Out Now in ACS Infectious Diseases on H. Pylori<\/em> work!<\/strong><\/h3>\n

The present study reports the development of methylpyrazole-substituted benzimidazoles as small molecule inhibitors of\u00a0<\/span>H. pylori<\/i>\u00a0IMPDH with a nanomolar range of enzyme inhibition.<\/span><\/strong><\/p>\n

Congratulations Haritha!<\/span><\/strong><\/p>\n

[\/et_pb_slide][et_pb_slide image=”http:\/\/labs.iitgn.ac.in\/ccbl\/wp-content\/uploads\/2024\/06\/Picture2.png” use_bg_overlay=”off” use_text_overlay=”off” _builder_version=”4.21.0″ header_font=”Georgia||||||||” background_color=”#ffffff” button_on_hover=”on” text_orientation=”justified” background_layout=”light” text_shadow_style=”preset1″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off” sticky_transition=”on”]<\/p>\n

Our New studies on Temozolomide cocrystals with enhanced dissolution, stability, and biological towards GBM is now published in JMS!<\/strong><\/h3>\n

Congratulations Bhanu, Delna, Gurudutt, Divita and team!<\/strong><\/p>\n

[\/et_pb_slide][et_pb_slide image=”http:\/\/labs.iitgn.ac.in\/ccbl\/wp-content\/uploads\/2023\/07\/Screenshot-2023-07-12-194026.png” use_bg_overlay=”off” use_text_overlay=”off” _builder_version=”4.21.0″ header_font=”Georgia||||||||” background_color=”#ffffff” button_on_hover=”on” text_orientation=”justified” background_layout=”light” text_shadow_style=”preset1″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off” sticky_transition=”on”]<\/p>\n

A recent review from our lab on exploring the pivotal role of ATR and ATM kinases in DNA damage and their promising inhibitors that are currently undergoing clinical trials. This cutting-edge research sheds light on the intricate mechanisms underlying DNA damage response and opens doors to potential breakthroughs in cancer therapy.<\/strong><\/h3>\n

[\/et_pb_slide][et_pb_slide image=”http:\/\/labs.iitgn.ac.in\/ccbl\/wp-content\/uploads\/2023\/05\/1.png” use_bg_overlay=”off” use_text_overlay=”off” _builder_version=”4.21.0″ header_font=”Georgia||||||||” background_color=”#ffffff” button_on_hover=”on” text_orientation=”justified” background_layout=”light” text_shadow_style=”preset1″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off” sticky_transition=”on”]<\/p>\n

SPK98 – a Torrin2 analog, was employed as an ATR kinase inhibitor.<\/b><\/h3>\n

Congrats Bhanu! <\/strong><\/h3>\n

[\/et_pb_slide][et_pb_slide image=”http:\/\/labs.iitgn.ac.in\/ccbl\/wp-content\/uploads\/2023\/05\/2.png” use_bg_overlay=”off” use_text_overlay=”off” _builder_version=”4.21.0″ header_font=”Georgia||||||||” background_color=”#ffffff” button_on_hover=”on” text_orientation=”justified” background_layout=”light” text_shadow_style=”preset1″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off” sticky_transition=”on”]<\/p>\n

A recent publication from our lab showed phenothiazines’ potency as a TLK inhibitor.<\/b><\/h3>\n

Congratulations, Delna and the team! <\/strong><\/h3>\n

[\/et_pb_slide][et_pb_slide image=”http:\/\/labs.iitgn.ac.in\/ccbl\/wp-content\/uploads\/2023\/05\/3.png” use_bg_overlay=”off” use_text_overlay=”off” _builder_version=”4.21.0″ header_font=”Georgia||||||||” background_color=”#ffffff” button_on_hover=”on” text_orientation=”justified” background_layout=”light” text_shadow_style=”preset1″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off” sticky_transition=”on”]<\/p>\n

Increased solubility with comparable potency of an ATP competitive inhibitor, Gefitinib.<\/b><\/h3>\n

Congo Althaf, Pranav, Dimple, and the team! <\/strong><\/h3>\n

[\/et_pb_slide][et_pb_slide image=”http:\/\/labs.iitgn.ac.in\/ccbl\/wp-content\/uploads\/2023\/05\/314887705_5791733520893938_620443328845210983_n.jpg” use_bg_overlay=”off” use_text_overlay=”off” _builder_version=”4.16″ header_font=”Georgia||||||||” background_color=”#ffffff” button_on_hover=”on” text_orientation=”justified” background_layout=”light” text_shadow_style=”preset1″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off” sticky_transition=”on”]<\/p>\n

New patent granted for J54 molecule<\/b><\/h3>\n

Congratulations to the entire team! <\/strong><\/h3>\n

[\/et_pb_slide][et_pb_slide image=”http:\/\/labs.iitgn.ac.in\/ccbl\/wp-content\/uploads\/2023\/05\/FvGw4KgacAAXK4r.jpg” use_bg_overlay=”off” use_text_overlay=”off” _builder_version=”4.21.0″ header_font=”Georgia||||||||” background_color=”#ffffff” button_on_hover=”on” text_orientation=”justified” background_layout=”light” text_shadow_style=”preset1″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off” sticky_transition=”on”]<\/p>\n

Recent patent granted for RAS inhibitors.<\/b><\/h3>\n

Kudos to the team! <\/strong><\/h3>\n

[\/et_pb_slide][et_pb_slide image=”http:\/\/labs.iitgn.ac.in\/ccbl\/wp-content\/uploads\/2022\/07\/7-17-22-11_39-AM-Microsoft-Lens-2_page-0001.jpg” use_bg_overlay=”off” use_text_overlay=”off” _builder_version=”4.16″ header_font=”Georgia||||||||” background_color=”#ffffff” text_orientation=”justified” background_layout=”light” text_shadow_style=”preset1″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off” sticky_transition=”on”]<\/p>\n

A glimpse of interview by Ms. Spoorty and Dr. Archana<\/strong><\/h3>\n

[\/et_pb_slide][et_pb_slide image=”http:\/\/labs.iitgn.ac.in\/ccbl\/wp-content\/uploads\/2022\/07\/1658411553925.jpg” use_bg_overlay=”off” use_text_overlay=”off” _builder_version=”4.16″ header_font=”Georgia||||||||” header_text_align=”justify” body_text_align=”justify” background_color=”#ffffff” text_orientation=”justified” background_layout=”light” text_shadow_style=”preset1″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off” sticky_transition=”on”]<\/p>\n

‘Dr. R Gopalan Endowment Prize 2022’ by Madras Christian College, Chennai<\/strong><\/h4>\n

[\/et_pb_slide][et_pb_slide image=”http:\/\/labs.iitgn.ac.in\/ccbl\/wp-content\/uploads\/2022\/07\/Screenshot_20220723-162026_Adobe-Acrobat.jpg” use_bg_overlay=”off” use_text_overlay=”off” _builder_version=”4.16″ header_font=”Georgia||||||||” background_color=”#ffffff” button_on_hover=”on” text_orientation=”justified” background_layout=”light” header_text_shadow_style=”preset1″ text_shadow_style=”preset1″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off” sticky_transition=”on”]<\/p>\n

Recent Publication on H. pylori\u00a0<\/em>IMPDH from our group<\/strong><\/h4>\n

[\/et_pb_slide][\/et_pb_fullwidth_slider][\/et_pb_section][et_pb_section fb_built=”1″ fullwidth=”on” _builder_version=”4.16″ global_colors_info=”{}”][et_pb_fullwidth_slider _builder_version=”4.21.0″ background_size=”contain” global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][et_pb_slide heading=”Our very recent startup – %22PBG Kinomics%22″ image=”http:\/\/labs.iitgn.ac.in\/ccbl\/wp-content\/uploads\/2023\/05\/PBG-kinomics.png” use_bg_overlay=”off” use_text_overlay=”off” _builder_version=”4.21.0″ header_font=”Georgia||||||||” background_color=”#ffffff” button_on_hover=”on” text_orientation=”justified” background_layout=”light” global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off” sticky_transition=”on”]<\/p>\n

Introducing a new drug candidate to the market is a complex and time-demanding process that at least costs pharmaceuticals an average of billion dollars and 10-15 years of research and development. Out of the four stages of drug discovery, the critical yet time-consuming process is identifying the hit and valid drug candidate for the target of interest. This process covers at least 5-6 years in the overall phase of drug discovery. Hence, reducing this gap would eventually decrease the time gap in identifying the hit molecules and fast-track the<\/strong>
drug discovery process.<\/strong>
Our previous findings with TTK, a protein kinase that is highly overexpressed in breast cancer, we aim to develop the protein kinase assay to screen our in-house designed small molecule as a TTK inhibitor. The project goals are to i) design and develop the protein expression and purification assay for TTK and ii) develop a protein inhibition assay for screening the small molecules. The project will further be taken up to more proteins to design the assay kit.<\/strong><\/h5>\n

[\/et_pb_slide][\/et_pb_fullwidth_slider][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Welcome Section” _builder_version=”4.16″ custom_padding=”0||3px||false|false” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ custom_padding=”27px|0px|0|0px|false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ global_colors_info=”{}”]<\/p>\n

Welcome to Sivapriya Kirubakaran’s lab<\/strong><\/h1>\n

The Modern Era of Cancer Therapeutics<\/strong><\/span><\/h3>\n

[\/et_pb_text][et_pb_image src=”http:\/\/labs.iitgn.ac.in\/ccbl\/wp-content\/uploads\/2022\/07\/7-17-22-11_39-AM-Microsoft-Lens.pdf” align_tablet=”center” align_phone=”center” align_last_edited=”on|desktop” _builder_version=”4.16″ global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ custom_padding=”0|0px|27px|0px|false|false” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.21.0″ global_colors_info=”{}”]<\/p>\n

What do we do as a researcher?<\/span><\/strong><\/h4>\n

Our laboratory focuses specifically on molecular <\/span>targets and their exploration in the discovery and development of selective cancer therapeutic agents. We employ strategies for the intelligent combination of therapeutic agents that are selective for a specific molecular target to produce an efficacious response and overcome the mechanisms of drug resistance.<\/span><\/h4>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_video src=”http:\/\/labs.iitgn.ac.in\/ccbl\/wp-content\/uploads\/2020\/07\/Your-Facebook-Video-fbdown.net_.mp4″ _builder_version=”4.16″ global_colors_info=”{}”] 
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IIT Gandhinagar<\/span><\/strong><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ text_font=”Source Sans Pro||||” text_text_color=”#ffffff” text_font_size=”18″ text_line_height=”2.2em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_padding=”0px|||” use_border_color=”off” border_color=”#ffffff” border_style=”solid” global_colors_info=”{}”]<\/p>\n

Members<\/a>
Research<\/a>
Publications<\/a>
Awards<\/a>
Highlights<\/a>
Collaborations<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ text_font=”Source Sans Pro||||” text_text_color=”#ffffff” text_font_size=”18″ text_line_height=”2.2em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_padding=”0px|||” use_border_color=”off” border_color=”#ffffff” border_style=”solid” global_colors_info=”{}”]<\/p>\n

Academics at IITGN<\/a>
Research at IITGN<\/a>
\u00a0IITGN News and Updates<\/a>
IITGN Campus<\/a>
IITGN Admissions<\/a>
IITGN Main Website<\/a><\/p>\n

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FOLLOW US<\/p>\n

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  “Here’s to a decade of groundbreaking discoveries, tireless research, and endless possibilities – Celebrating 10 years of excellence in SVL lab!”Recent Lab News Out Now! Much-awaited Paper. TLK1 as a therapeutic target in TMZ-resistant glioblastoma using small-molecule inhibitors! This study sheds light on the role of TLK1 in the context of TMZ resistance, highlighting […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-template-blank.php","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"

This is an example page. It's different from a blog post because it will stay in one place and will show up in your site navigation (in most themes). Most people start with an About page that introduces them to potential site visitors. It might say something like this:<\/p>

Hi there! I'm a bike messenger by day, aspiring actor by night, and this is my website. I live in Los Angeles, have a great dog named Jack, and I like pi\u00f1a coladas. (And gettin' caught in the rain.)<\/p><\/blockquote>

...or something like this:<\/p>

The XYZ Doohickey Company was founded in 1971, and has been providing quality doohickeys to the public ever since. Located in Gotham City, XYZ employs over 2,000 people and does all kinds of awesome things for the Gotham community.<\/p><\/blockquote>

As a new WordPress user, you should go to your dashboard<\/a> to delete this page and create new pages for your content. Have fun!<\/p>","_et_gb_content_width":"","footnotes":""},"class_list":["post-2","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/labs.iitgn.ac.in\/ccbl\/wp-json\/wp\/v2\/pages\/2","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/labs.iitgn.ac.in\/ccbl\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/labs.iitgn.ac.in\/ccbl\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/labs.iitgn.ac.in\/ccbl\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/labs.iitgn.ac.in\/ccbl\/wp-json\/wp\/v2\/comments?post=2"}],"version-history":[{"count":77,"href":"http:\/\/labs.iitgn.ac.in\/ccbl\/wp-json\/wp\/v2\/pages\/2\/revisions"}],"predecessor-version":[{"id":206784,"href":"http:\/\/labs.iitgn.ac.in\/ccbl\/wp-json\/wp\/v2\/pages\/2\/revisions\/206784"}],"wp:attachment":[{"href":"http:\/\/labs.iitgn.ac.in\/ccbl\/wp-json\/wp\/v2\/media?parent=2"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}